Sophomore guard Anthony Johnson handed out a game-high eight assists without committing a turnover, and Byrd added four of his own as the Boilermakers totaled 23 on the night.
In addition to holding the Wolves to 35.3 percent shooting for the game, Purdue forced 22 Newberry turnovers and turned them into 28 points. Ronnie Johnson had three steals to pace the Boilers to 12 on the evening, and junior forward Travis Carroll blocked four shots on the night to lead the team to a total of eight.
Purdue outrebounded Newberry by a count of 52-34, including a margin of 33-16 after halftime. Anthony Johnson's seven boards on the night were a game high, while junior Sandi Marcius and freshman A.J. Hammons snagged six each. Carroll also chipped in with five rebounds.
The Boilers held a 28-12 edge in second-chance points on the night.
Purdue will open regular-season play on Friday against Bucknell at 7 p.m.