Starting cornerback Jerraud Powers was placed on injured reserve Monday and will be lost for the season with a toe injury, the Indianapolis Colts announced.
Defensive tackle Drake Nevis was also put on injured reserve, ending his season.
To adjust to the losses, the Colts activated nose tackle Josh Chapman from the reserve/non-football injury list and promoted tight end Kyle Miller from the practice squad to the active roster. Chapman was a fifth-round draft pick out of Alabama who has yet to play his first NFL down.
Powers had 45 tackles as a starter in the Colts' first eight games and had an interception early that helped the Colts stage a comeback win over the Green Bay Packers.