She used her final speech in Australia in the city of Adelaide, the heartland of Australia's military manufacturing industry, to reject criticisms that Australia's enhanced ties with the United States would come at the cost of its burgeoning relationship with China.
"I know there are some who present a false choice: That Australia needs to choose between its longstanding ties to the United States and its emerging links with China," Clinton said.
"Well, that kind of zero-sum thinking only leads to negative-sum results," she added.
Clinton's comments followed a speech on Wednesday by former prime minister Paul Keating, a hero of the ruling Labor Party, in which he said Australia's "former sphere of influence is diminishing."
Keating blamed a lack of foreign policy independence, arguing that Australia had "rolled backed into an easy accommodation with the foreign policy objectives of the United States."
Speaking hours before China's new leadership was announced in Beijing, Clinton said the United States supported Australia's foreign policy objectives in the Asia-Pacific region.
"We support Australia having strong multifaceted ties with every nation in the Asia-Pacific, indeed in the world, including China, just as we seek the same," she said.
"The Pacific is big enough for all of us," she added.
Clinton made one of the longest journeys of her four years as secretary of state to fly for a jading 31 hours from the United States to the Australian west coast city of Perth to attend the security summit on Wednesday.
The summit agreed that Australia will host two U.S. space surveillance systems and to expand the number of U.S. Marines rotating through an Australian training hub from 200 this year to 1,100 by 2014. Up to 2,500 Marines will eventually use the facility.
The U.S. military also plans to make greater use of Australia's Indian Ocean naval base and northern warplane bombing ranges under agreements announced by President Barack Obama a year ago that have riled China.
Carr noted that the agreement reached on Wednesday included "no language of containment," in a reference to accusation that the United States plans to contain China's growth.
Speaking at a shipyard where U.S. contractors are involved in the $8 billion construction of three destroyers for the Australian navy, Clinton emphasized the economic spin-offs for both countries from the U.S.-Australian alliance.
She said the United States was Australia's third-largest trading partner after China and Japan and two-way trade was increasing. The United States was also the biggest investor in Australia with direct investments totaling $136 billion.
She said the security and economic relations between the two countries were both indispensable and must be developed.
"This economic relationship is just as vital to both of our nations' continued strength as our defense partnership because in today's world, power is increasingly measured and exercised in economic terms," she said.