William & Mary (7-4) was led by Marcus Thornton with 21 points and Tim Rusthoven with 16 points and six rebounds. The Tribe dropped to 1-5 all-time against Big Ten schools.
Purdue struggled to put the game away until a late surge. Each time it looked like the Boilermakers were about to pull away, the Tribe came right back.
But Jacob Lawson broke a 58-58 tie with a layup with 7:46 to go, and the Boilermakers outscored William & Mary 13-8 the rest of the way.