Frank Gaines scored a team-high 18 points on 7-of-17 shooting from the field, while freshman forward Joe Reed scored a career-high 15 points, hitting six of his seven shots in the game. Reed also pulled down six rebounds to lead the team, while Isaiah McCray dished out four assists to pace the squad.
The teams battled back-and-forth in the first half to seven tie scores and four lead changes, as the largest lead gained by either team would be four by the Jackrabbits early in the contest.
IPFW (8-11, 1-4 SL) came out firing to start the second half, scoring the period's first eight points on a three from McCray, a jumper from Gaines, and a three-pointer from Luis Jacobo to lead by five at 39-34.
A Reed basket with 15:44 gave the Mastodons a one-point, 42-41 lead, the team's final lead of the game, as South Dakota State (13-6, 4-2) scored the next 14 points, as the margin never reached single digits again.
The 26 points are the most that the Dons have been outscored by this season, as the team had not trailed by more than 19 in any of the previous 18 games.
IPFW shot 22-of-52 from the field (42.3 percent), 3-of-18 (16.7 percent) from long range, and 10-of-18 (55.6 percent) from the charity stripe.
South Dakota State was 30-of-54 shooting in the game, 55.6 percent, while going 7-of-13 on three-point attempts, and 16-of-25 on free throws.
IPFW was outrebounded 33-to-31, with Gaines grabbing four boards, while Joe Edwards had a team-high three steals with Gaines and Reed each grabbing two.
Nate Wolters, who fueled SDSU's second-half run, scored a game-high 29 points on 10-of-18 shooting, while Marcus Heemstra and Chad White each scored a dozen points in their winning effort.
The Mastodons will host South Dakota on Thursday at 7 p.m. at the Coliseum.