Purdue shot 49 percent from the field and outrebounded the Mountaineers 44-34.
Eron Harris scored 10 points for West Virginia, which barely surpassed its season low of 50 points. Harris was the only Mountaineers player to reach double figures. The Mountaineers (8-9) have lost three straight and four of five.
West Virginia shot just 29 percent from the field, and the Mountaineers had six assists and 17 turnovers.
It was the third consecutive opponent Purdue has held below 34 percent shooting. Penn State shot 26 percent Sunday in Purdue's 60-42 win and Nebraska shot 33 percent as the Boilermakers prevailed 65-56 in Lincoln, Neb., on Wednesday night.