The girl died in the I-275 pileup near the Cincinnati suburb of Colerain Township. At least 20 injured people were taken to hospitals.
The State Highway Patrol says an estimated 50 vehicles were in a pileup on I-75, between Middletown and Monroe. Minor injuries were reported.
And the patrol says four semitrailers and about 20 cars were involved in an afternoon pileup on I-71 near Mansfield.
Lanes of I-270 have been reopened following a multi-vehicle crash near Columbus.