Spring Arbor eventually built a 45-26 halftime lead and at one point in the second half, led by as many as 29 points.
"They were picked to finish third in the conference and they played like a team with something to prove," Saint Francis coach Chad LaCross said in a release. "It's disappointing because I don't think we ever really competed. There is really not much more to say except that Spring Arbor wanted it more. We just didn't compete."
Josh Hogan led the Cougars with 14 points including 4-for-6 shooting from 3-point range. Scott Kohne, the reigning Crossroads League Player of the Week, finished with 12 points, while freshman Kyle Sovine came off the bench to score a career-high 11 points in the loss.
The visiting Cougars had five players reach double figure scoring led by Chris Bellamy with 18. Matt Van Pelt added 16 points in the win, while teammates Rob Hogans (15), Matt Carden (11) and Peter Barry (10) also contributed.
Spring Arbor shot 57.4 percent (31 for 54) from the floor, while Saint Francis connected on just 32.8 percent (22 for 67).
Kohne grabbed a team-high nine rebounds and Saint Francis did outrebound Spring Arbor 40-34, including 22-8 on the offensive glass.
The visitors outscored Saint Francis 42-24 in the paint.
Saint Francis will travel to Goshen on Saturday at 3 p.m.