Saint Francis senior guard Ethan Hussey pitched in 16 points, while classmate Kevin Bloom added 15, and sophomore Josh Hogan finished with 11.
The win helped Saint Francis (18-12, 10-8 CL) end a two-game skid. After finishing sixth in the conference, the Cougars will travel to No. 3-seeded Bethel College (21-9, 12-6 CL) to start the CL Tournament.
"We got some transition baskets off our defense," Hussey said in a release. "Then we just started knocking down shots from everywhere. It's a good feeling to head into the tournament with, a confidence that we are a good team."
Saint Francis led Mount Vernon Nazarene 38-32 at halftime after the visitors led in the first half by as many as five points with 6:33 to play in the half.
The score was tied six times and there were six lead changes before Bloom gave the Cougars the lead for good with a free throw at 3:19 that broke a tie at 29.
Saint Francis outscored Mount Vernon Nazarene (11-19, 3-15) 12-5 in the final 4:01 of the first half.
The Cougars climbed to its first double-digit lead on two Hussey free throws at 18:18 for a 45-34 advantage.
Kohne scored for a 48-38 Saint Francis lead with 15:48 to play and it went on a 22-8 run that opened up a 70-46 spread with 4:26 to play in the game.