The Saints shot almost 45 percent from the floor for the game, while holding Indiana Tech to just 30 percent.
Rachael Kruse led all scorers with 24 points, while Warrior teammate Chelsea Carradine notched her eighth double-double of the season with 12 points and 11 rebounds.
Kruse knocked down a three-pointer to start to the game and Kaneisha Bass followed with bucket of her own to give the Warriors a quick 5-0 lead. But 11 straight points from Siena Heights put the Saints in front for good.
After trailing 42-30 at halftime, the Warriors opened the second stanza on a 12-3 run, getting nine points from Kruse, to cut the deficit to three at the 17:22 mark.
Indiana Tech stayed close for the next nine minutes, but couldn't get any closer. Holding a 58-54 lead with under nine minutes to play, the Saints pulled away and put the game out of reach with a 13-1 run over the next four minutes.
Kruse, a Homestead High School graduate, hit a season-best four three-pointers on the night and added seven rebounds. Ulyssia Richmond contributed 12 points for Indiana Tech.
Indiana Tech ends the season with a 13-18 record, 11-11 in conference play, and finished in sixth place in the WHAC.