Stefanie Mauk led IPFW with 16 points, as she shot 6-of-15 from the field. Mauk had a trio of 3-pointers, while Amanda Hyde was the only other Mastodon to score in double figures. She added 12 points, seven rebounds, three steals, and two assists.
Western Illinois sank 11 of its 24 attempts (45 percent) from long range, including five from Saule Kontautaite, while Michelle Maher was close behind with four.
Maher ended the game with 16 points, seven rebounds, four assists and a block. Kontautaite scored a game-high 17 points.
Trailing 6-0, IPFW scored the next five points to narrow the gap, but another Leatherneck run put the Leathernecks up 16-5 with 12:57 to play in the first half.
The double-figure lead got up to 16 points in the first half after a pair of free throws from Jackie Rieger, but Murphy scored the last field goal of the first half to put the score at 38-24.
The start of the second half also went Western Illinois' way, as the Leathernecks quickly opened up a 20-point lead at the first media timeout.
The Mastodons cut the deficit to 13 after a 3-point field goal from Hyde, but Kontautaite answered with a 3-pointer on the next possession to regain the momentum.
Western Illinois came out on top of all the hustle-point categories. It scored 19 points off IPFW turnovers and also won the points in the paint battle 26-14.
The Leathernecks scored 10 second chance points and outscored the IPFW bench 12-5.
The Mastodons will travel to IUPUI on Saturday.