Later, she spoke about young people who commit suicide after suffering from bullying. Noting that she has teenage kids of her own, she said the situation is "an atrocity to me and I don't accept it."
She then called on the audience to join her in a "revolution" to change the world.
Madonna was on hand to give Anderson Cooper the organization's "Vito Russo" award. Others honored included director Brett Ratner and the TV series "Smash."