"It is a tremendous venue with a uniquely intimate setting that has made it a very special place for fans and artists alike," said Bret Gallagher, Live Nation's President of North American Concerts for Southern California and Las Vegas.
Gallagher said details will be soon announced for a series of summer farewell shows before the closure. Fans who were planning to attend concerts scheduled for after September are advised to hold on to their tickets as Live Nation makes arrangements for performances at different venues.
The 6,100-seat space opened as the Universal Amphitheatre in 1972, an outdoor venue at Universal Studios.
The mid-sized space with was loved by everyone from head bangers to heads of state for its intimate setting with superior sound. Bob Dylan, David Bowie, Madonna, Kanye West, the Grateful Dead and many other major artists performed there.
Other headliners included Presidents Barack Obama, Bill Clinton and George H.W. Bush.
And the amphitheater also hosted comedians like Jay Leno, Eddie Murphy and Louis C.K.
The closure makes way for the "Wizarding World of Harry Potter," an attraction that's part of a major theme park and studio expansion by property owner NBCUniversal.