A police officer spotted the van at about 1:20 a.m. in Crawfordsville, a city about 30 north of Greencastle. He stopped it in a store parking lot and ordered the girls out of the vehicle, Riley said.
"The driver put the van into reverse, struck the police car, and attempted to run the officer down. The officer fired several rounds at the van to protect himself," Riley said.
The officer returned to his crashed police car and chased the van, which the girls abandoned about a block away and fled on foot.
The officer captured one of the girls, and other Crawfordsville and Montgomery County Sheriff's officers arriving on the scene captured the other three, Riley said.
Unspecified charges against the girls will be forwarded to the Montgomery County Prosecutors Office, Riley said.
ResCare's website says it treats boys and girls with behavior problems from across Indiana.
Further details on the girls, their hometowns and why they traveled to Crawfordsville were not released.