The Hoosiers (49-14) will face Mississippi State (49-18) on Monday night. Mississippi State advanced with a 5-4 win over Oregon State.
DeNato threw a career-high 136 pitches en route to a four-hit shutout. He struck out eight batters and walked three. His complete game means IU has a fully rested bullpen for Monday night.
The Hoosiers, who are 6-0 in NCAA tourney action this season, have won three of four games against Louisville this season. It's the second time they have beaten the Cardinals 2-0, both with DeNato as the starter.
Louisville (51-13) will play Oregon State (50-12) on Monday in an elimination game in this double-elimination event.
Earlier on Saturday, Indiana coach Tracy Smith was named national coach of the year after leading the Hoosiers to their first ever College World Series.
Up nextIndiana vs. Mississippi State, 8 p.m., Monday, College World Series.