They scored twice in the first inning and five times in the third, when they chased Guthrie (7-5) from the game. De Aza's homer came off reliever Bruce Chen in the sixth.
Most of that offense turned out to be moot the way Santiago (3-5) was pitching.
The left-hander gave up just three hits and a walk, and Eric Hosmer's homer in the sixth represented the only run Santiago has allowed to the Royals in 19 1-3 career innings.CLEVELAND — Scott Kazmir allowed one run in seven strong innings and Jason Kipnis drove in three, leading the Cleveland Indians to a 5-1 win over the Minnesota Twins on Friday night.
Kazmir (4-4) gave up just a leadoff homer to Brian Dozier in the sixth and four other hits. The left-hander struck out seven, including five in his final two innings. Kazmir has been a pleasant addition for the Indians, who signed him during the winter after he pitched for the independent Sugarland Skeeters last season.
Kipnis hit a sacrifice fly — to the second baseman — off Samuel Deduno (3-2) in the third and added a two-run single in the seventh as the Indians won their third straight and seventh in nine games since losing eight in a row.