Colts coach Chuck Pagano confirmed Monday an MRI revealed a torn ACL (anterior cruciate ligament), which will end Wayne's season and a streak of 189 consecutive games played.
"We hate to lose anybody, but this one stings," Pagano said. "You don't replace guys like (No.) 87."
Wayne rolled over, grabbing his knee, then stayed down on the field while being attended to by team medical personnel. He eventually walked off the field under his own power, but reaction shots of his pain led many to believe the injury was worse than the “sprained knee” the team initially reported.
Some have speculated that Wayne's injury could be career-threatening since he is in his 13th year and will turn 35 next month.
He told Pagano he will return to play again next season, and Pagano has no doubts.
"He's not going out like this," Pagano said. "He's not going to leave this game like this. There's no way. So he'll fight, he'll get his surgery, he'll rehab and he'll grind like nobody's ever grinded and he'll do whatever it takes to get back on that football field, even if it's to catch one more pass or make one more block to help this football organization. But he's not going out like this."
Pagano made reference to Wayne wearing orange gloves in support of Pagano during his fight with leukemia last season. Pagano said he and the team will be wearing gloves in support of Wayne.
"We'll be there for him every step of the way," Pagano said.
Wayne leads the Colts with 38 catches for 503 yards and has two touchdowns.
Colts center Sam Satele, defensive back Darius Butler, defensive back Josh Gordy and linebacker Mario Harvey also suffered injuries in the game.