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Medical advice: When weight gain follows cancer

Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.The Associated Press

It can be a side effect of chemotherapy.

Monday, June 16, 2014 12:01 am
Q: My sister had breast cancer (hormone receptor positive) and pulled through beautifully, but now she's gaining a lot of weight. She swears she isn't eating more or exercising less. What's going on? — Kate D., Syracuse, NYA: Weight gain is sometimes the unfortunate side effect of chemotherapy, and most women with hormone-receptor positive (HR+) cancer also experience menopause because of the chemo. That can be a weight-gain double whammy. Chemotherapy, and maybe menopause, changed your sister's metabolism, and she can't eat or exercise like she did before and expect the same results.

Once you're overweight, excess body fat causes inflammation (and can lead to elevated blood sugar). Inflammation (and elevated blood sugar) activates genes and proteins that fuel cancer growth. The risk of weight gain is especially severe in cases of HR+ breast cancer. A new study looked at 80,000 women with HR+ breast cancer and found that women with BMIs above 30 had a 21.5 percent chance of dying during a 10-year period — about a 33 percent increased risk over women with HR+ breast cancer who were at a healthy weight.

To counter the risk, your sister might work with a nutritionist who can help her establish a healthy, anti-inflammatory diet and help her keep her blood sugar low. Next, she can start a good walking program (find guides at www.sharecare.com and get a pedometer!).

Q: My husband and I are having a hard time getting pregnant, and I hear everyday products may be damaging to guys' sperm. What's that all about? — Jennifer C., Phoenix

A: We're sorry that you're struggling to become pregnant. Many factors can interfere with conception. (See our book “YOU: Having a Baby.”)

For women, they include problems with ovulation, fibroids and alterations in cervical mucus. For men and women, excessive exercise, a diet laden with saturated fats and/or sugars, obesity, smoking, excess alcohol and especially stress can interfere. So do some environmental chemicals. These include endocrine (hormone) disruptors in personal-care products, cosmetics, fragrances and plastics. Both BPS and BPA in plastics may interfere with hormones that help sperm swim and help sperm find an egg to fertilize.

Also identified as trouble-causers: 4-methylbenzylidene camphor (4-MBC) used in sunscreens to block UVB rays; di-n-butylphthalate (DnBP), a known toxin used to make plastics more flexible and found in carpet backings, paints, glue, insect repellents, hairspray and nail polish; and triclosan, in antibacterial soaps and toothpastes. These may inhibit sperm production, alter sperm's swimming style and cause a sort of “premature ejaculation” of an enzyme that helps a sperm fuse with an egg.

There are tests that can look for the source of your fertility problem. And you both may need to make lifestyle adjustments: increasing physical activity; eating a healthier diet with more DHA-omega-3's; not drinking so much or smoking at all; and sleeping more. There may also be physical problems your doctor or a surgeon could treat.

While pursuing those possible solutions, both of you can also try to reduce exposure to hormone-disrupting chemicals. Avoid canned foods; never heat food in plastic in the microwave; don't use any plastic items with 3, 6, or 7 on the recycle label. Read all personal-care product labels to avoid phthalates, and stay clear of the other chemicals mentioned above.


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