Colson's double-double was his ACC-best 18th of the season.
Ky Bowman scored 19 points and Mo Jeffers had 12 points and 12 rebounds for Boston College (9-21, 2-15 ACC), which has lost 13 in a row and 15 of 16, including a Feb. 14 home game against Notre Dame in which the Eagles let a 10-point lead slip away in the second half.
The Irish again got off to a slow start against BC, falling behind by seven in the first half before ripping off 15 straight points. Beachem knocked down two 3-pointers during the run and Boston College went over 6 minutes without a field goal.
Beachem had 15 points as the Irish took a 36-28 lead.
Matt Farrell and Rex Pflueger hit consecutive 3-pointers to cap a 10-2 run that extended the Irish lead to 16 points with 11:31 to play. Farrell finished with 14 points.
Beachem turned in the highlight of the game with a baseline drive and twisting scoop shot from behind the backboard with 6:40 to play.
Boston College: The Eagles dropped to 0-8 on the road in ACC play, have not beaten Notre Dame in nine straight, and have not won in South Bend since 1997.
Notre Dame: With a win at No. 8 Louisville, combined with a North Carolina loss to Duke on Saturday, the Irish would earn a share of the ACC regular season title.
Playing their last home game at Purcell Pavilion, seniors Steve Vasturia and Beachem have helped the Irish win 94 games during their four years, tying them for the fifth-most wins in program history, three away from matching the 97 victories the 2009-10 class compiled.
Boston College: The Eagles finish the regular season at Clemson on Saturday.
Notre Dame: The Irish also play their regular season finale on the road, at No. 8 Louisville on Saturday.